Factbox: Drugmakers bulk up with bets on weight-loss treatments

Melissa Eide

May well 12 (Reuters) – Zealand Pharma (ZELA.CO) and partner Boehringer Ingelheim on Wednesday introduced beneficial demo facts for their weight-reduction treatment and joined the race for a share of a global weight problems drug current market that is anticipated to contact $100 billion inside of a decade.

Extra than 50 % a dozen organizations are producing pounds-decline therapies identical to Novo Nordisk’s (NOVOb.CO) Wegovy, with Eli Lilly and Co’s (LLY.N) tirzepatide commonly envisioned to be the next to strike the market place.

The pursuing is a record of businesses focusing on the following significant blockbuster chance:


Novo Nordisk’s (NOVOb.CO) weekly injection Wegovy was authorized in 2021. It will work by mimicking a hormone referred to as glucagon-like peptide-1 (GLP-1) that triggers the feeling of fullness in the physique soon after having.

The firm also experienced an older products Saxenda, permitted in 2014, but Wegovy is regarded safer and far more efficient.

Novo stated last week it would have to halve the offer of starter doses of Wegovy in the U.S. to cope with large need.


Eli Lilly (LLY.N) said very last month its diabetic issues procedure Mounjaro served people today with type 2 diabetes who had been also obese or chubby to eliminate just about 16% of their overall body excess weight in a significant demo.

The drug, also identified as tirzepatide, is expected to get a U.S. acceptance for body weight reduction afterwards this year.

Tirzepatide activates the body’s receptors for gastric inhibitory polypeptide (GIP) and GLP-1, which are pure hormones and observed in regions of the brain important for urge for food regulation.


Pfizer Inc (PFE.N) and Japanese lover Sosei Heptares’ (4565.T) experimental oral GLP-1 drug, PF-07081532, is staying examined in a mid-phase trial to address kind 2 diabetes and being overweight.

The enterprise said it programs to enroll some sufferers in its late-stage demo who have by now made use of Wegovy or Mounjaro to present they can efficiently swap to Pfizer’s oral alternative.


Amgen Inc’s (AMGN.O) experimental obesity drug, AMG133, confirmed promising toughness trends in an early-stage trial late previous 12 months.

The drug applicant confirmed mean fat loss of 14.5% soon after 12 months of procedure at the maximum month to month dose. It has a twin mechanism which targets GLP-1 and GIP.

The organization stated it plans a bigger mid-stage study this yr.


Altimmune Inc (ALT.O) in March explained its experimental being overweight drug, pemvidutide, served lessen weight by above 10% on normal in a mid-stage demo.

Nevertheless, the drug prospect also confirmed basic safety fears with sufferers encountering nausea and vomiting of mild and average severity.

Pemvidutide is a dual motion drug that targets GLP-1 and also imitates one more gut hormone known as glucagon, which will help burn up much more unwanted fat when performing exercises and stops the destructive develop-up of extra fat in the liver.


Viking Therapeutics Inc’s (VKTX.O) experimental being overweight drug, VK2735, confirmed up to 6% reduction in mean body weight in an early-phase analyze.

The organization options to examination greater doses of the drug over a for a longer period remedy window in a mid-stage trial and expects final results from an early-stage extension study to appraise oral doses by the center of the year.

VK2735 is also a dual motion drug that targets both GLP-1 and GIP receptors.


Denmark’s Zealand Pharma (ZELA.CO) and Boehringer Ingelheim’s experimental weight problems treatment method attained up to 14.9% bodyweight reduction in a mid-phase demo on Wednesday.

The drug prospect, BI 456906, also targets GLP-1 and GIP receptors.

OPKO Wellness
Opko Well being (OPK.O) has finished a mid-phase trial of its weight problems drug, pegapamodutide, that it expects will have much less aspect results. The latest GLP-1 drugs can induce nausea and vomiting.

China’s LeaderMed has agreed to produce and sell Opko’s compound in the region. The company is also in talks with larger sized drugmakers in Western countries for a partnership.

Reporting by Mariam Sunny and Pratik Jain in Bengaluru Enhancing by Sriraj Kalluvila

Our Expectations: The Thomson Reuters Rely on Ideas.

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